17 Comments

-- ARTIFICIAL MELATONIN CAN BE TOXIC / DEADLY / CAUSE BLINDNESS ...!!

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No, not really...no more than masturbation.

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Magnesium spray at night works really well

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Haven't heard of oral spray, but I'm a big supporter of oral magnesium, when it's properly chelated for bio absorption. It immediately eliminates restless leg syndrome in many women, and it helps to safely promote sleep. The brand I recommend is found in my insomnia treatment plan: https://us.fullscript.com/plans/markmcdonaldmd-insomnia.

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Have you read the book “Spark” by John Ratey, MD?

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No, haven't heard of it.

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Yes the spray in the dermis kind works wonders for muscular pain deep sleep enhanced Serotonin release and bypasses the gut so you have no risk of diarrhea. Wonderful for kids with autism and ADHD when they’re flying off the wall calms them down without drugging them up

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Spray on skin

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Never heard of that before--sounds like an excellent product!

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Any thoughts on liquid melatonin for sublingual absorbtion? I've always wondered what kind of oral bioavailability melatonin tabs have. I can think of another endogenous tryptamine, also produced in the pineal gland, which is completely metabolized in the GI tract before entering circulation.

There could be other benefits too, i.e. faster onset of sleepiness. There aren't many studies on sublingual melatonin.

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I haven't yet seen a liquid melatonin supplement available for sale, but I don't see why it wouldn't work as well, if not better, than an oral capsule, for the reason you mention.

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I'm really interested in this research on melatonin for respiratory and attention issues. I struggled with many respiratory issues when I was a young man and found that nose breathing and raising my CO2 levels was something that had a profound effect on respiratory issues as well.

https://mattcook.substack.com/p/why-its-so-important-to-nose-breathe

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Yes--breathing through the nose is far superior for many reasons, both physical and mental.

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I've never once met a healthy mouth breather.

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The times I've taken it before bed I've had nightmares. I think it was 10 mg. Do you find this be a side effect in your patients as well?

By the way, enjoyed meeting you at the Florida Covid Summit - your books are excellent.

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Thanks for your support! Yes, high-dose melatonin (10 mg) does provoke vivid dreams in some people, which is why I recommend low-dose sustained release. It avoids this problem, along with reducing the risk of affecting endogenous melatonin production.

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November 27, 2023
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I believe the sustained release comes from the way the molecule is processed by Designs For Health, rather than any added ingredients. The ingredient list is short and contains only innocuous binding and encapsulating agents like cellulose and vegetable fats.

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